Anastasios Mantelis was born in Athens in 1945 and studied Law at the University of Athens. He is a lawyer at the Supreme Court and the State Council.
He was elected a member of the Parliament representing Kefalonia with PASOK in 1981 for the first time. He was the president of OTE (1985- 1988) and the Greek Post Offices (1985- 1989). In 1993 he was the General Secretary of the Ministry of Industry, Energy and Technology.
In January 1996 Kostas Simitis appointed him General Secretary of the cabinet. He was the undersecretary of the Ministry of the Interiors, Public Administration and Decentralization and later, in September 1997, Minister of Transportation and Communication. In 2000ís National Elections he was elected a member of the Parliament for the Bí constituency of Athens. He is married with Efthimia Vlachou and they have two children, Aggelina and Haralambo.